Wednesday, February 20, 2013

Inhibitor Recommendation for Cell Signaling Research

Bioactivity of the Inhibitors

Stratech Scientific would like to recommend Selleck Chemicals inhibitors targeting Tie-2 of angiogenesis related signaling pathway for your excellent research.

MGCD-265
MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of Met, VEGFR1, VEGFR2, VEGFR3, Ron, and Tie2 with IC50 of 1 nM, 3 nM, 3 nM, 4 nM, 2 nM and 7 nM, respectively.

XL-184 (Cabozantinib)
XL184 (Cabozantinib) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.

Tie2 kinase inhibitor
Tie2 kinase inhibitor is a potent and selective Tie2 inhibitor with IC50 of 0.25 μM.



Where can I find more information about Selleck Chemicals?

Visit the manufacturer page at www.stratech.co.uk/selleck_chemicals, email info@stratech.co.uk or call +44 (0) 1638 782600.

Stratech Scientific is a distributor of high quality, competitively priced, reliable products for research laboratories throughout the UK and Europe. Please contact us to find out which ranges we can supply in your country.
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