Friday, October 3, 2014

Product Focus: Anti-mouse CD31 / DIA-310 Rat monoclonal anti-mouse endothelial cell marker CD31 (PECAM-1), Clone SZ31

Antibody clone SZ31 is the first antibody which reacts specifically with murine CD31 in formalin-fixed paraffin-embedded tissue sections.

CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) is expressed constitutively on the surface of embryonic and adult endothelial cells. It is also expressed on cell surfaces of monocytes, neutrophils, platelets and certain T-cell

subsets. It has been detected on bone marrow-derived hematopoetic stem cells and embryonic stem cells. CD31 is a 130kDa integral membrane glycoprotein and as a member of the immunoglobulin superfamily involved in the mediation of cell-to-cell adhesion.

CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Studies have shown CD31 to be a superior marker in human angiogenesis, which reportedly predicts tumor recurrence. Pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were excluded. The clone SZ31 eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.

Product Information

MSDS        Datasheet


Catalogue numbers: DIA-310 (100μg)
DIA-310-M (20μg)
Specificity: CD31
Species Reactivity: Mouse
Host Species: Rat
Isotype: IgG2a
Clone: SZ31
Clonality (Mono-/Polyclonal): monoclonal
Application: Immunohistochemistry (IHC), Paraffin Sections (PS), Frozen Sections (GS), Western Blot
Conjugation: unconjugated
Format: lyophilisate, antibody purified (from culture supernatant)
Intended Use: for Research Use Only
Research Area: angiogenesis, CD markers, immunohistochemistry  

Where can I find more information about Dianova?

Visit the manufacturer page at, email or call +44 (0) 1638 782600.

Stratech Scientific is a distributor of high quality, competitively priced, reliable products for research laboratories throughout the UK and Europe. Please contact us to find out which ranges we can supply in your country.
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