Friday, October 3, 2014

Product Focus: Anti-mouse CD31 / DIA-310 Rat monoclonal anti-mouse endothelial cell marker CD31 (PECAM-1), Clone SZ31

Antibody clone SZ31 is the first antibody which reacts specifically with murine CD31 in formalin-fixed paraffin-embedded tissue sections.

CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) is expressed constitutively on the surface of embryonic and adult endothelial cells. It is also expressed on cell surfaces of monocytes, neutrophils, platelets and certain T-cell

subsets. It has been detected on bone marrow-derived hematopoetic stem cells and embryonic stem cells. CD31 is a 130kDa integral membrane glycoprotein and as a member of the immunoglobulin superfamily involved in the mediation of cell-to-cell adhesion.

CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Studies have shown CD31 to be a superior marker in human angiogenesis, which reportedly predicts tumor recurrence. Pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were excluded. The clone SZ31 eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.


Product Information

MSDS        Datasheet

 

Catalogue numbers: DIA-310 (100μg)
DIA-310-M (20μg)
Specificity: CD31
Species Reactivity: Mouse
Host Species: Rat
Isotype: IgG2a
Clone: SZ31
Clonality (Mono-/Polyclonal): monoclonal
Application: Immunohistochemistry (IHC), Paraffin Sections (PS), Frozen Sections (GS), Western Blot
Conjugation: unconjugated
Format: lyophilisate, antibody purified (from culture supernatant)
Intended Use: for Research Use Only
Research Area: angiogenesis, CD markers, immunohistochemistry  


Where can I find more information about Dianova?

Visit the manufacturer page at www.stratech.co.uk/dianova, email info@stratech.co.uk or call +44 (0) 1638 782600.

Stratech Scientific is a distributor of high quality, competitively priced, reliable products for research laboratories throughout the UK and Europe. Please contact us to find out which ranges we can supply in your country.
Post a Comment