Tuesday, February 24, 2015

Application Examples of SynVivo Technology in Action

SynVivo products are a physiological, cell-based microchip platform that provides a morphologically and biologically realistic microenvironment allowing real-time study of cellular behavior, drug delivery and drug discovery.

SynVivo’s patented technology for recreating microvasculature scale, shape, fluidics, and cellular constructs provides the most realistic in vitro testing platform for drug discovery, delivery, efficacy, and toxicity assays.

The examples below are specific applications of SynVivo’s technology to set examples where this system can bridge the gap to in vivo.


 

Migration Assays

Imagine an assay which is repeatable, simple to use, provides real-time live cell imaging and gives data which matches in vivo observations. SynVivo has overcome the limitations of Transwell® assays to provide an entirely new system for studying migration in a realistic and dynamic environment.



 

Nanopolymer Delivery for Gene Therapy

A nanopolymer used for drug delivery was complexed with GFP DNA and perfused on tumor cell (HeLa) cultured networks. GFP transfection, efficiencies and distribution was quantified at 24 hours post injection.



 

Targeted Drug Delivery

A confluent layer of endothelial cells were activated with cytokines. Anti-ICAM-1 coated particles were used for targeting (red dots) and IgG particles served as controls (green dots). Data was obtained at 4 and 24 hours post treatment.



 

Drug Particle Adhesion

P-selectin, an inflammatory molecule was coated on the walls of SynVivo. Particles coated with the antibody to P-selectin were injected into SynVivo and their differential binding pattern was observed.



 

Drug Perfusion

SynVivo were injected with trypan blue and the perfusion of the dye was observed in real-time.




Where can I find more information about SynVivo?

Visit the manufacturer page at www.stratech.co.uk/synvivo, email info@stratech.co.uk or call +44 (0) 1638 782600.

Stratech Scientific is a distributor of high quality, competitively priced, reliable products for research laboratories throughout the UK and Europe. Please contact us to find out which ranges we can supply in your country.


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